Mesonephric like adenocellomas (MLAs) arise from the mesonephric corpus of the ovary or uterus and can take on a number of different growth patterns. While these tumors may have a myriad of possible etiologies, they are usually categorized as serous carcinomas. When the disease has metastasized, it may have reached other organs, including the liver and lungs.
A patient with mesonephric-like adenocarcinoma presented to her medical oncologist with abdominal and flank pain 18 months after undergoing right salpingo-oophorectomy. Further, she underwent total abdominal hysterectomy, pelvic lymphadenectomy, and infra-colic omentectomy. She was diagnosed with Stage IA mesonephric like adenoma. Eighteen months post-operatively, she developed a recurrent symptom, which was a sign of a recurrence of the tumor. Her physician referred her to medical oncology for chemotherapy.
A recent review of mesonephric-like adenocarcinomas found that these tumors were extremely aggressive, even when they were diagnosed at a relatively low stage. A study by Yap et al. examined 31 cases of MNAC, in which a third of patients had a local recurrence following curative resection, and one fifth had a fatal course within nine years.
There is no way to determine if a tumor is mesonephric if it has a mesonephric morphology. But a mesonephric-like adenocarcinoma has the hallmarks of ovarian cancer, with a low-grade serous adenocarcinoma and mesonephric-like glioma, but it is difficult to separate the two from each other.
Molecular markers of mesonephric-like adenocarcinoma can help in the diagnosis. In addition to this, a patient with mesonephric-like ovary may have a positive thyroid transcription factor 1 (TTF1) mutation. If this is the case, the patient should be evaluated with chemotherapy and other available therapies.
Mesonephric-like adenocarcinomas are rare in utero. A 60-year-old woman was diagnosed with a mesonephric-like adenacarcinoma and an associated tumor. The cancerous mass was characterized by a protruding cancerous mass. It was diffusely enriched for PAX8 and GATA3 and adenocarcinoma-like adenocarcinoma-related protein called EMA.
Adenocarcinoma is the most common cancer of the ovaries. Its symptoms include abdominal pain and heavy bleeding. In some cases, mesonephric-like adenocarcinoma can be asymptomatic or recurrent. A biopsy is usually necessary to confirm the diagnosis. Symptoms of mesonephric-like ovaries vary widely.
Mesonephric-like adenocarcinomas are highly aggressive even when they are diagnosed in early stages. In a study published in 2009, a meta-analysis of 31 MNACs reported that 85% of the patients presented at stage 1 had a local recurrence of the disease after treatment. However, the tumor was not atypical in forming other lesions.
A rare type of mesonephric-like adenocarcinomas occurs in the ovaries. This is a rare type of tumor that often affects women. A symptomatic woman presenting with symptoms of abdominal discomfort may be at risk for a mesonephric-like neoplasm. She had a tumor in the left ovary and an abscess but no tumor in her ovaries. A cancerous mass was found in the left side of the uterus. The cancerous mass was composed of various types of cells with different growth patterns. The patient had a negative serum level of EMA.
The diagnosis of mesonephric-like adenocarcinoma is atypical. The mesonephric remnant epithelia may either be benign or malignant. It is possible for mesonephric-like ducts to develop in the lungs and liver. Despite the similarities, the mesonephric-like morphology of mesonephric adenocarcinoma is often misdiagnosed as endometrioid endometrial adenomyoid adenocarcinoma can be atypical.
The tumors in mesonephric-like adenocarcinomas exhibit a typical immunophenotype of mesonephric adenocarcinomas and are classified as mesonephric-like mucinous adenocarcinomas. The two types of cancer share a common histological appearance.
A mesonephric-like adenocarcinoma is a rare type of adenocarcinoma. Its pathology is similar to that of mesonephric adenocarcinomas but is not mesonephric. These tumors also show signs of hyperplasia in the mesonephric region, but lack mesonephric remnants.